Interleukin 1 (IL-1)- and IL-23-Mediated Expansion of Filarial Antigen-Specific Th17 and Th22 Cells in Filarial Lymphedema

Filarial Lymphedema Is Characterized by Antigen-Specific Th1 and Th17 Proinflammatory Responses and a Lack of Regulatory T Cells

BACKGROUND Lymphatic filariasis can be associated with development of serious pathology in the form of lymphedema, hydrocele, and elephantiasis in a subset of infected patients. METHODS AND FINDINGS To elucidate the role of CD4(+) T cell subsets in the development of lymphatic pathology, we examined specific sets of cytokines in individuals with filarial lymphedema in response to parasite ant...

Malaria and Filarial Coinfections Multifunctional Th1 and Th17 Responses in Filarial Infection Suppresses Malaria-Specific

Myiasis in human filarial lymphedema.

Chrysomyia spp. are common causes of myiasis in different parts of Asia (Harwood and James, 1969). Extensive studies on the biology of some of the Chrysomyia spp. had been carried out by Norris and Murray (1964). Zumpt (1965), and Oothuman and Jeffery (1984) summarized the literature on human myiasis caused by these flies. Recently Lee (1985), and Lee and Yong (1991) reported cases of oral and ...

Cytokines (IL-17, IL-23, and IL-33) in Systemic lupus erythematosus in Trinidad and Tobago.

Systemic lupus erythematosus (SLE) is the most common autoimmune disease. It is characterized by the presence of hundreds of autoantibodies against many organs and tissues, including the presence of a large number of autoantibodies, which are specific to self-antigens mainly of nuclear origin such as Smith antigen, double-stranded DNA (dsDNA), anti-Sjögren’s syndrome-related antigen A and B (SS...

Nutritional control of IL-23/Th17-mediated autoimmune disease through HO-1/STAT3 activation

The nutritional curcumin (CUR) is beneficial in cell-mediated autoimmune diseases. The molecular mechanisms underlying this food-mediated silencing of inflammatory immune responses are poorly understood. By investigating antigen-specific immune responses we found that dietary CUR impairs the differentiation of Th1/Th17 cells in vivo during encephalomyelitis and instead promoted Th2 cells. In co...